Richard Feynman was probably the most original mind of the mid-twentieth century. He also clearly had Aspergers Syndrome (AS).
His autobiographies (ghostwritten by his friend Ralph Leighton) Surely You're Joking, Mr. Feynman and What do you Care what Other People Think are instantly recognizable to anyone with AS or who works with AS people.
The title of SYJ refers to a typical example of an AS person's confusion with social situations. The chapter heading "a Different Box of Tools" is a pretty good description of the AS mind. "The Dignified Professor" contains the story of how girls he met at Cornell refused to believe he was a professor, and therefore refused to date him for boasting (AS people often seem younger than they are because they do not easily learn social skills that are part of what is considered maturity). "You just Ask them?" is Feynman using sheer intellectual horsepower to mimic 'normal' human behavior (in this case picking up women).
The title of WDYCWOPT refers to Feynman's first wife teaching him to be less nervous in social situations - a common task for wives of AS men. The book also contains his appendix to the Challenger Commission report. This is remarkable for its slightly naive tone (like many AS people, Feynman has little idea what is reasonable behavior to expect from a bureaucracy) and the fact that it would have been equally relevant to the other shuttle disaster. In the "Gumshoes" chapter he relates a typical situation in which an AS person (Feynman)accidentally upsets a 'normal' person (Dr. Keel).
The most dramatic example of his AS is probably that his first lecture on what became known as Feynman diagrams was universally rejected by the physics establishment just after the war. Twenty years later he was given a Nobel prize for this work.
I could go on, because almost everything written by or about Feynman is littered with clues to his AS.
His adopted daughter, Michelle, edited his letters. She speculates why her father is more famous and popular than other Nobel Prizewinners. First, his work was far more fundamentally important even than that of the 'average' laureate. Second, his AS, and his attempts to manage it, demonstrated that one does not have to be flawless to achieve great things, a pleasant idea for many people.
The letter described as the first one he wrote from Los Alamos to his mother mentions "my ever-present gastronomical difficulties": many AS people have gastrointestinal problems and allergies. Feynman eventually died of abdominal cancer at age seventy.
http://www.seattlechannel.org/videos/video.asp?ID=3013 is a marvelous discussion including Michelle.